Royal Air Force Typhoon jets have conducted a mission with French warplanes in a coordinated attack on an hidden munitions depot in Syrian territory used by the IS group, according to the UK's MoD.
The site, pinpointed through reconnaissance, was assessed as storing arms and explosives, the release indicated, and was positioned in hills just to the north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets used precision-guided Paveway IV munitions to target a series of approach shafts leading to the facility... initial indications indicate the strike was effective," the ministry announced.
There was no sign of any civilian impact in the strike on Saturday evening and each participating jet returned safely, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
IS - also known as Daesh - imposed jihadist rule over parts of Iraq and Syria until 2019.
"This action demonstrates our UK leadership, and commitment to work closely with our partners, to stamp out any resurgence of IS and their dangerous and violent ideologies in the Middle East," UK Defence Secretary John Healey remarked.
RAF aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted comeback" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I extend gratitude to every member of our armed forces participating in this operation for their expertise and their courage," Healey said. "They were among thousands of British personnel stationed over the holidays. This mission, to take out militants who endanger our security, shows how UK forces are ready to step up, all year round, protecting the UK domestically and powerful internationally."
In December, the US military conducted what it called a "large-scale strike" on IS targets in the country, subsequent to an attack resulted in the deaths of two US troops and a civilian interpreter in the Palmyra area.
The UN reports Islamic State still has between 5,000 and 7,000 combatants in Syria and Iraq.